Goodbye, Mrs. Wolowitz.

Carol Ann Susi, the actor who played Howard's overbearing (unseen) mother on "The Big Bang Theory," has died at the age of 62 from an aggressive form of cancer. She made her first "appearance" on the show's seventh episode and became a popular recurring character despite never showing up on screen.

"'The Big Bang Theory' family has lost a beloved member today with the passing of Carol Ann Susi, who hilariously and memorably voiced the role of Mrs. Wolowitz," said Warner Bros. Television, CBS and "Big Bang" producers Chuck Lorre, Steven Molaro and Bill Prady in a statement. "Unseen by viewers, the Mrs. Wolowitz character became a bit of a mystery throughout the show’s eight seasons. What was not a mystery, however, was Carol Ann’s immense talent and comedic timing, which were on display during each unforgettable appearance. In addition to her talent, Carol Ann was a constant source of joy and kindness to all. Our thoughts and deepest condolences are with her family during this time, and we will miss her greatly."

Originally from Brooklyn, Susi studied acting at New York's famed HB Studio before moving to Los Angeles in the 1970s. Her first major role was as Kolchak's secretary Monique Marmelstein on the hit ABC series "The Night Stalker." In addition to guest roles on a number of other series including "Cheers," "Doogie Howser, M.D.," "Seinfeld" and "Six Feet Under," she was also active in L.A.'s theater scene.

She is survived by her brother Michael Susi, his wife Connie and "multitudes of friends."

Sound off with your tributes in the comments.

A former contributor to sites including MTV's The Backlot and Bloody-Disgusting, Chris Eggertsen worked in film development before indulging his love of pop culture writing full time. He specializes in horror, the intersection of social issues and entertainment and Howard Stern. He's on Twitter @HitFixChris.