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Chloe Sevigny - Alex Lowe
Now: In "AHS: Hotel," Sevigny plays Alex Lowe, wife of Detective John Lowe (Wes Bentley). A mother and doctor, Alex is grappling with a major loss, so of course John has his wife somehow enmeshed in the action as he investigates a gory serial killer at the Hotel Cortez. Because... just because, alright?