Will 'The Heat's' Sandra Bullock and Melissa McCarthy join the list?
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6. 'Planes, Trains and Automobiles' (1987)
Many buddy movies rely on the friction between the two pals before reconciliation, no more so than in this transportation tale, where a lovable lummox played by John Candy proves to be a major irritant to an increasingly agitated Steve Martin as they both attempt to get home for the holidays. Just remember, "Those aren’t pillows."