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"Comedy Central Roast of Charlie Sheen" (2011)
Though Amy Schumer had established her brand of slick sarcasm on standup shows before, she felt like a breath of fresh air when she razzed Charlie Sheen (and Mike Tyson, memorably) during his Comedy Central Roast. Host Seth MacFarlane said in her introduction that he'd never heard of her before, but by show's end it was clear she was one of the few triumphant performers. She was a success again at the following year's roast of Roseanne Barr.