Should Varys and Theon form a support group? Could Brienne topple the Mountain? And how quickly could Jon Snow kill Ramsay?
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Jon Snow & Daenerys
This one also seems inevitable, given that the title of the book series is "A Song of Ice and Fire," and these are the two characters who most represent those temperature extremes. But other than Bran Stark (and Hodor), no major character on the series is further away from Dany at the moment, so this will require a lot of movement, in terms of both geography and plot, to get them together. And by the time that happens, will one or both of them have conquered the doubts and impulsiveness that have characterized both of their attempts at leadership?