With last year's winner Zeljko Ivanek out of the field, is the door open for a 'Lost' or 'Grey's Anatomy' star?
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John Mahoney of 'In Treatment'
John Mahoney, "In Treatment"
Nomination Status: Your favorite
Bottom Line: Because of David Hyde Pierce, John Mahoney never won an Emmy for "Frasier." We were actually a little surprised to realize that. So what we have here is a respected industry legend most decorated for his comedy work playing a powerfully dramatic role on a show that's already proven to be a fertile ground for Emmy wins? Barring something strange or surprising, Mahoney has to be considered the man to beat here, lining himself up for a potential Career Summation-style Emmy, a well-deserved one at that.