The Joker? Magneto? Anton Chigurh? Who made the list?
Syndrome - 'The Incredibles'
Ever wonder what would happen if a wannabe superhero sidekick went to the dark side? Meet Buddy Pine, aka Syndrome. Years ago, Pine was Mr. Incredible's greatest fan. When the World's Greatest Superhero turned down his request to be his no. 2, Pine spent years planning his revenge against a (now retired) Mr. Incredible and his super-powered family. Gleefully voiced by Jason Lee, Syndrome falls into the "what a jerk" category of villains, but as goofy as he is you know he'll stop at nothing to avenge his shattered ego (well, as far as you can go in a Pixar movie of course).
- Gregory Ellwood