Just who exactly are these A-holes?
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Origin allusion: After a lifetime chaffing under the all-seeing eye of her adopted father and plethora of unnamed siblings, Gamora turns traitor to help save the people of Xandar. The question becomes how is Gamora considered Thanos's favorite daughter when she loathes him for killing her entire family? A skilled assassin and privy to Thanos's unwavering trust, the fact she never exacted revenge on him leaves the true nature of their relationship murky.
But wait: Somehow comic Thanos is more altruistic than his movie counter-part. He rescues the baby Gamora during the genocide of her people, the Zen-Whoberi, by the Universal Church of Truth. Thanos then uses advanced technology to bring Gamora quickly to adulthood…though he does not enhance her body with modifications nor torture her into loving him. Instead he merely alters her perceptions so she cannot see his evil nature. With a doting, devoted daughter tailor made, Thanos sends her out into the Universal Church of Truth to assassinate the leader and avenge her family. It is only later that Gamora realizes the truth about her "father" and turns on him.
So what now? The Marvel cinematic universe has been known to use comic plots out of order if they make sense for the cinematic universe. As a founding member of the Guardians, among other things, there are still plenty of reasons for Thanos to seek out his wayward daughter and entrap her in an Infinity Stone for her betrayal. There's still time for Gamora to found the female warrior group known as The Graces with Nebula as a member. And there's definitely still time for the Universal Church of Truth to rear its head to sow chaos.