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50. Laurie Metcalf
"Roseanne" might be remembered for delivering the titular standup comic's rancor with notes of sentimentality and family values, but the show wouldn't be an all-time great without the spastic, impeccably timed work of Laurie Metcalf as Aunt Jackie. Metcalf, a Steppenwolf Theatre alum who won an Obie Award for her performance in "Balm in Gilead," was both cartoonishly grand and spastically real as the exhausted Jackie. She picked up three Emmys for Best Supporting Actress in a Comedy Series, and it's not difficult to see why: All these years later there's no one as exasperated or as funny as Aunt Jackie. Metcalf now stars on what I promise is the most underrated comedy on TV, HBO's "Getting On."
- Louis Virtel