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"The Tree of LIfe"
Pro: One of the most critically acclaimed films of the year, it also did fine art house business over the summer. It will also be a primary player for New York Film Critic's and LA Film Critic's year-end honors which could cement it's nomination chances.
Con: The film is not universally understood and may be a bit too much of an art film for the Academy. Star Sean Penn's comments over the summer regarding the editing of the picture haven't been forgotten either (at least by the media).