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Keira Knightley, "A Dangerous Method"
Pro: As Sabina Spielrein, one of the first psychoanalysts, Knightley arguably delivers one of the best performances of her career as a young woman who goes from being an actual mental patient to a pioneer in psychology. Knightley should impressive her fellow actors as she pulls the foreign accent card (Russian) and some startling scenes where Spielrein tries to rein in her "hysteria" while undergoing experimental (at the time) therapy sessions.
Con: David Cronenberg's period drama is respected, but critics hardly adore it. It's unclear how its overtly intellectual screenplay will play with the Academy. Some publicists also believe Knightley should be in the best supporting actress and not lead actress category.