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Drew Barrymore, "Everybody's Fine"
Previous nominations or wins: None
Pros: Barrymore is at that point of her career where the right dramatic role can push her over the top for a cumulative career nomination. Her acclaimed work in "Grey Gardens" and fine notices for directing "Whip It" don't hurt either. But...
Cons:...nobody knows yet whether "Fine" is a true Oscar contender or a dramedy pretender. Plus, her reputation for being a diva while filming and promoting "Whip It" isn't going to endear her to a good chunk of the Academy.
[Left, Drew Barrymore with Robert De Niro in a scene from "Everybody's Fine."]