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Charlize Theron, "The Road"
Previous nominations or wins:
Won, Best Actress, "Monster" (2004)
Nominee, Best Actress, "North Country" (2006)
Pros: A true supporting role, Theron plays a character greatly expanded from the novel, but hardly in the film itself, Viggo Mortensen's wife. In a short amount of screen time, she conveys the desperation and exhaustion her character feels as she can no longer face living after years of trying to survive in a post-apocalyptic world.
Cons: If the dark and depressing "Road" is not embraced by Academy members or critics it's hard to see her or anyone from the film getting recognized.