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Wes Anderson, "The Fantastic Mr. Fox"
Previous nominations or wins:
Nominee, Best Original Screenplay, "The Royal Tenenbaums" (2002)
Pros: Anderson surprised all the naysayers by delivering arguably one of his best films in the adaptation of Roald Dahl's classic children's book. "Fox" stays true to the original source material, but has Anderson's specific vision all over it. Even though it's animated, his peers may find the achievement hard to ignore.
Cons: Like Docter for "Up," the fact "Fox" isn't a live action flick really hurts Anderson's chances. Plus, if either of the fwo filmmakers make it, it's probably Docter.
[Left, George Clooney and Wes Anderson at the world premiere of "The Fantastic Mr. Fox."]