Director: Jay and Mark Duplass
Starring: Jason Segel, Judy Greer, Susan Sarandon, Ed Helms
Why:  The Duplass brothers are building a great, quirky filmography, and they've somehow made the jump to working with bona-fide movie stars without losing any of the loose, shaggy charm of their hyper-indie roots.  Their last movie "Cyrus" was a masterwork of the uncomfortable, and just the title for this one makes me hoot with laughter.  It's a great starting point for two guys who have proven time and again that they can find the epic in the intimate, and they're at a point where audiences are about to catch up.