Jodie Foster will shoot you. I'm sure of it.
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Charlize Theron as Aileen Wuornos in "Monster"
Aileen Wuornos: not one of the cheerier figures in this category. She has a criminal past and finds herself spiraling further into horror by killing a rapist in self-defense, then losing her mind and murdering a bunch of johns for their money. Doesn't seem like you can work your back up from that. Charlize Theron is both chilling (especially during the scenes with johns when she's convinced they're all trying to rape her) and heartbreaking (namely during scenes with her lover Selby, played by Christina Ricci). Even when you eliminate the homicide quotient, she is rugged as hell and could arm-wrestle you to death. Stay away.