O'Donnell also informed fans of her previous show to be prepared for a new attitude. "it's going to be different from the old show in that when I was 33 I think the appeal of my program was there was an authentic, genuine appreciation of pop culture. I loved these people, like Streisand and Tom Cruise, the concept that I could meet them was really beyond my belief, and now I'm 50, and both of those people have stayed in my house, right?  So the enthusiasm that I had for celebrities is changed.  I have evolved and grown, and the show is going to be reflective of that."

With the show airing at 7 p.m., O'Donnell is putting a twist on late night talk. "It's gonna be one celebrity per show, and they're going to have something to talk about and want to come and play and have a fun kind of 60 minutes together, and there will be an upfront part, like your standard late night fare where I'll do my kind of comedy.  I'm not a monologist. I don't ba dum dum kind of jokes."

She'll also add a game to end each show; her attempt to live out a long held dream. "You know my goal in life was to host 'The Price is Right.'  It has been in every TV contract I've ever signed.  Should Bob Barker retire, this is my contractual out, and then he retired, and I begged them, and they chose Drew Carey," she said, quickly adding, "He's doing a fine job."

Though O'Donnell wants comedian Russell Brand (and Adele) for guests, she won't be tackling (at least not intentionally) is controversy. "But as things come up in life and in the world, you know, if we were on in the last few months, I'm sure that we would have had someone talking with me one day, perhaps, about the fascination with the Casey Anthony trial, because as a child advocate my whole life and career, I don't really understand why the media and the nation focused on this one child when there are many children killed and tortured every day.  I don't know why this one became the kind of news driver that it did, and I would like to approach that from a sociological or an anthropological point of view as to why we, as a culture, consume media in the way we do.  So we're not going to look for controversy, but should it be germane to what's happening in the world, I'm sure we will bring up current events." She then referenced her own checkered talk show past, joking,  "Not in a way like attacking Tom Selleck or anything, because once you've done that once, really..."

"Rosie" debuts 7/8 p.m. ET/PT Oct. 10 on OWN.